The objective of this article was to establish the clinical course of interstitial lung disease (ILD) in scleroderma related to the presence of anti-PM/Scl antibody compared with anti-Scl-70 in a Spanish cohort. Furthermore, no study has thoroughly investigated the outcome of pulmonary function test in the first group of patients.
14 days ago
The increased incidence of malignancies in systemic sclerosis (SSc) accounts for about 10 percent of the mortality in this disease. In 1979, a study showed that 4 percent of SSc patients developed cancer, most commonly breast cancer, followed by lymphoma/leukemia, gastrointestinal malignancy and cervical cancer. Subsequent studies demonstrated high standardized incidence ratios (SIR) of overall cancer, lung, bladder and liver cancer, and hematologic malignancies.