Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation.
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Our objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses’ Health Study (NHS, 1984–2014) and 93,572 women in the NHSII (1991–2013); incident RA was confirmed by medical records.
In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity that affects joints.
Smoking is Associated with low levels of soluble PD-L1 in Rheumatoid Arthritis
The safety of treatment with biological disease-mod- ifying antirheumatic drugs (bDMARD) has been carefully studied for the past 15 years; however, it is still largely unknown whether this treatment is safe in patients with arthritis with a history of cancer.
This study found no association between the presence of ACPAs, other autoantibodies commonly occurring in rheu- matological diseases, or cigarette smoking, and lymphoma risk in RA. These results suggest that other mechanisms are involved in the development of lymphoma in patients with RA, and that the search for biomarkers that can predict development of lymphoma in RA must be continued.
Multicenter Cross-sectional Study of Patients with Rheumatoid Arthritis in Greece:
Results from a cohort of 2.491 patients
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and ulcerative colitis?
The influence of disease-modifying anti-rheumatic drugs and corticosteroids on the association between rheumatoid arthritis and skin cancer: a nationwide retrospective case-control study in Taiwan
During the last few years, a relationship between smoking and autoimmunity has been demonstrated. Smoking habit is emerging as a possible environmental trigger for several autoimmune diseases.