Our objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses’ Health Study (NHS, 1984–2014) and 93,572 women in the NHSII (1991–2013); incident RA was confirmed by medical records.
Since the peripheral cytokines, produced after the injection of the vaccines, are able to reach the central nervous system, we hypothesize that these cytokines can have effects on the microglia (macrophages of the central nervous system), and that these effects can be facilitated by repeated vaccinations to infants during the first year of life.
Ferritin, which was only discovered in the last century, has stirred a
formidable debate. Ferritin has long been appreciated as a non-specific acute-phase reactant. Several years ago, we hypothesized the contributory role of ferritin as a pathogenic molecule rather than being a product of inflammation. The latest emerging evidence provides support to this notion. Such revelation provides a step forward towards the understanding of disease conditions associated with hyperferritinaemia, and hence provide new targets for treatment modalities.
In his Review article (Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome.