Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS).
This study presents interferon-alpha (IFN-α)-induced persistent fatigue as a model of CFS. IFN-α, which is used in the treatment of chronic Hepatitis C Virus (HCV) infection, induces persistent fatigue in some individuals, which does not abate post-treatment, that is, once there is no longer immune activation.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease
Chronic fatigue syndrome (CFS) is a multifaceted disorder causing profound debilitating fatigue negatively influencing one’s quality of life and functional capacity. CFS is a clinical diagnosis of exclusion and is given when other etiologies for fatigue have been ruled out.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry
A critical review of randomized trials and post-marketing case series