Category: Autoimmunity
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which demyelination and neurodegeneration occurs. The immune system of MS patients is characterized by a dysregulation in the balance between pro- and anti-inflammatory immune cells, whereby both the innate and adaptive immune system are involved
SSc is a complex rheumatoid disease characterized by autoimmunity, fibrosis, and vasculopathy. Mouse models provide powerful research tools for exploring the pathogenesis of human diseases
Giant—cell arteritis (GCA) is a large—vessel vasculitis usually affecting individuals over 50 years old, typically presenting with unilateral or a bilateral headache, myalgias, fatigue, fever, weight loss, and sometimes acute vision loss.
As the clinical symptoms of the antiphospholipid syndrome (APS) frequently occur irrespective of the syndrome, diagnosis predominantly depends on the laboratory assays measuring the level or function of antiphospholipid antibodies (aPLs).
The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune/inflammatory diseases. More recently, they have been associated with liver diseases. This review first describes the general knowledge on IL-17 and IL-17 producing cells.
Systemic Sclerosis (SSc) is a rare autoimmune disease that is characterized by progressive skin fibrosis, an obliteration of the microvasculature and an exaggerated extracellular matrix deposition, which lead to multisystemic dysfunction.
This study presents interferon-alpha (IFN-α)-induced persistent fatigue as a model of CFS. IFN-α, which is used in the treatment of chronic Hepatitis C Virus (HCV) infection, induces persistent fatigue in some individuals, which does not abate post-treatment, that is, once there is no longer immune activation.
Autoimmune rheumatic diseases including systemic lupus erythematosus, rheumatoid arthritis, Sjogren's Syndrome and progressive systemic sclerosis require both a genetic predisposition and an environmental exposure for disease onset and flares, and two or more of these diseases can develop in the same patient.
Close to 30 years ago we [Y.S. et al.] came up with the notion that autoimmune diseases share a common background which they had termed the mosaic of autoimmunity.
Several epidemiological studies have investigated the link between silicone breast implants (SBIs) and autoimmune/rheumatic disorders, reporting inconsistent results. We aimed to evaluate the association between SBIs and the most clinically relevant autoimmune/rheumatic disorders using a large, population-based database.