The antibody-mediated encephalitides occur in persons of all ages, with some types affecting predominantly children and young adults. Certain syndromes are recognizable on clinical grounds, and their autoimmune cause can be established with laboratory tests. Despite the severity of symptoms, prompt diagnosis and treatment lead to improvement or full recovery in most cases.
Cognitive impairment is a significant clinical problem both in multiple sclerosis (MS) and systemic lupus erythematosus (SLE) patients. In MS cognitive dysfunction has been associated with brain atrophy and total demyelinating lesion volume. In SLE cognitive impairment is much less understood, and its link to structural brain damage remains to be established.
Minocycline is a semi-synthetic antimicrobial which, in addition to its role in infectious disease, has garnered roles in the management of acne vulgaris, acne rosacea, and a variety of novel clinical applications (1). In the context of a potentially expanding population on protracted treatment courses, immune-mediated adverse effects, although rare, remain important to recognize.
The safety of treatment with biological disease-mod- ifying antirheumatic drugs (bDMARD) has been carefully studied for the past 15 years; however, it is still largely unknown whether this treatment is safe in patients with arthritis with a history of cancer.
The main objective of this study was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role.
Organ specific immune-related adverse events
are uncommon with anti-PD-1 drugs but the risk
is increased compared with control treatments. General adverse events related to immune activation are largely similar. Adverse events consistent with musculoskeletal problems are inconsistently reported but adverse events may be common.
Regular physical activity (PA) is increasingly promoted for people with rheumatic and musculoskeletal diseases as well as the general population. This article provides the evaluation of if the public health recommendations for PA are applicable for people with inflammatory arthritis (iA; Rheumatoid Arthritis and Spondyloarthritis) and osteoarthritis (hip/knee OA) in order to develop evidence-based recommendations for advice and guidance on
PA in clinical practice.
This study reports about elevated plasma levels of endocannabinoidome lipid mediators in fibromyalgia (FM). The lipids suitability to work as biomarkers for FM in the clinic were low,
however their altered levels indicate that a metabolic asymmetry is ongoing in FM, which could serve as basis during explorative FM pain management.
Birth rates in the United States have recently fallen. Data suggest that the HPV vaccine is associated with a lowered probability of having been pregnant. Several case studies link the HPV shot to POF suggesting one mechanism through which the vac- cine affected fertility might involve ovarian damage. Other mechanisms through which the HPV shot might influence the probability of con- ceiving also exist.
This study found no association between the presence of ACPAs, other autoantibodies commonly occurring in rheu- matological diseases, or cigarette smoking, and lymphoma risk in RA. These results suggest that other mechanisms are involved in the development of lymphoma in patients with RA, and that the search for biomarkers that can predict development of lymphoma in RA must be continued.