Category: Autoimmunity
Some studies suggest that there is an increased risk of malignancies in giant cell arteritis (GCA). We aimed to describe the clinical characteristics and outcomes of GCA patients with concomitant malignancy and compare them to a GCA control group.
Specific differences in cancer risk have been observed between systemic lupus erythematosus (SLE) patients and the general population. In past decades, various studies have investigated the relationship between SLE and malignancy
Presence of circulating antinuclear antibodies (ANAs) in patient serum is widely regarded as the hallmark of systemic autoimmune rheumatic disease [1]. A request for a serological ANA screening test is usually a first step for the laboratory diagnosis
The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such is phosphorylcholine (PC) moieties which are a component of secreted products of helminths.
Systemic lupus erythematosus (SLE) is primarily a relapsing-remitting (RR) disease with unpredictable flares interspersed with periods of clinical quiescence of varying duration. Initial studies on the patterns of disease activity over time described three different subgroups of patients: long quiescent, RR and chronically active after 4.5 years of follow up
Human papillomavirus (HPV) infection is a well-known sexually transmitted disease. A review of 70 countries worldwide showed an age-stratified HPV prevalence ranging from
Originally, neutrophil granulocytes were described to phagocytose and kill bacteria. In 2004, a second mechanism in which neutrophils trap bacteria with extracellular DNA (NETs) was described by Brinkmann et al.
The intention of this paper is to review actual developments in target therapy in SLE. Target therapy includes both the objective of intervention and the aim of treatment. The objective should be linked to the pathophysiologic process of SLE; the aim has to be in any case an improved outcome.
Increased expression of RNA polymerase 1 (POL1) molecular pathway was reported to be associated with increased disease activity in patients with multiple sclerosis (MS). However, the operating molecular mechanisms that characterize the pattern of acute MS relapse activity has not been thoroughly studied.
In the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias,myalgias, pyrexia, dry eyes, and dry mouth