Category: Autoimmunity
Although anti-TNFα agents have revolutionized the treatment of many inflammatory diseases, various concerns have been reported regarding the risks of cancer development, as well as acceleration of the progression of subclinical, pre-existing malignancies.
Regulatory T-cells (Tregs) can facilitate immune evasion by tumor cells by dampening anti-tumor immunity. Reduced Teff/Treg ratio and enhanced Treg functional activity have been observed in patients suffering from different types of cancers, and attenuated Treg numbers/functions can serve as prognostic indicators.
In the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L, such as tetrahydrocannabinol -THC) and cannabidiol (CBD), and their efects on infammation and cancer-related pain.
Our understanding of the pivotal role the immune system plays in the pathogenesis of many diseases is continually expanding. Huge advances have been made in elucidating the complex immunologic background of several diseases, including Alzheimer’s disease, Parkinson’s disease, and asthma [1,2].
Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system with a typical presentation of acute paralysis and hyporeflexia. Intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) are treatments that have proven to expedite recuperation and recovery of motor function.
Cannabidiol is a non-psychotropic component of cannabis sativa. Known to induce an immunomodulatory effect, cannabidiol’s therapeutic properties have been explored in a number of autoimmune diseases.
The concept of secondary fibromyalgia (FM) has garnered increasing interest over the last decade. This has resulted from the realization that many common rheumatic disorders have an FM comorbidity that influences or should influence, optimal management.
Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use
The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such is phosphorylcholine (PC) moieties which are a component of secreted products of helminths
Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS).