Presence of circulating antinuclear antibodies (ANAs) in patient serum is widely regarded as the hallmark of systemic
autoimmune rheumatic disease . A request for a serological
ANA screening test is usually a first step for the laboratory diagnosis
The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such is phosphorylcholine (PC) moieties which are a component of secreted products of helminths.
4 days ago
Systemic lupus erythematosus (SLE) is primarily a
relapsing-remitting (RR) disease with unpredictable flares interspersed with periods of clinical quiescence of varying duration. Initial studies on the patterns of disease activity over time described
three different subgroups of patients: long quiescent, RR and chronically active after 4.5 years of follow up
6 days ago
Human papillomavirus (HPV) infection is a well-known sexually transmitted disease. A review of 70 countries worldwide showed an age-stratified HPV prevalence ranging from
8 days ago
Originally, neutrophil granulocytes were described to phagocytose and kill bacteria. In 2004, a second mechanism in
which neutrophils trap bacteria with extracellular DNA
(NETs) was described by Brinkmann et al.
11 days ago
The intention of this paper is to review actual developments in target therapy in SLE. Target therapy includes both the objective of intervention and the aim of treatment. The objective should be linked to the pathophysiologic process of SLE; the aim has to be in any case an improved outcome.
13 days ago
Increased expression of RNA polymerase 1 (POL1) molecular pathway was reported to be associated with increased disease activity in patients with multiple sclerosis (MS). However, the operating molecular mechanisms that characterize the pattern of acute MS relapse activity has not been thoroughly studied.
In the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are
described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias,myalgias, pyrexia, dry eyes, and dry mouth
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which demyelination and neurodegeneration occurs. The immune system of MS patients is characterized by a dysregulation in the balance between pro- and anti-inflammatory immune cells, whereby both the innate and adaptive immune system are involved
SSc is a complex rheumatoid disease characterized by autoimmunity, fibrosis, and vasculopathy. Mouse models provide powerful research tools for exploring the pathogenesis of human diseases