The relationship between serum cytokine levels and degree of psychosis in patients with schizophrenia
10 days ago
Autoantibodies to the dense fine speckled 70 (DFS70) antigen are common among antinuclear antibodies (ANA) positive healthy individuals (HI). We assessed the prevalence of anti-DFS70 antibodies in patients with and without ANA-associated rheumatic diseases (AARDs) by two methods: chemiluminescent immunoassay (CIA) and an indirect immunofluorescence (IIF) assay based on immunoadsorption for DFS70.
10 days ago
The current paradigm in disease etiopathogenesis implicates the interplay of genetic and environmental factors. Multiple genes have been linked to susceptibility of patients to develop T1DM, including the human leukocyte antigen (HLA) loci HLA-DRB1 and DQB1.
Autoimmune disease are brought about by the inability of our immune system to identify self-antigens due to intrinsic loss of tolerance. Autoimmune diseases can be classified into either systematic or organspecific diseases. The central dogma in autoimmune diseases is their etiopathogenesis. Large strides in understanding the complex processes that drive disease emergence have been made in the past decades, however ongoing investigation is warranted. The current paradigm in disease etiology points towards the complex interplay between environmental triggers and epigenetic deregulations in genetically susceptible
hosts. A variety of environmental factors have been proposed including viral infections, exposure to smoke, hormones, stress,
drugs, pollutants and dietary factors among others.
In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity that affects joints.
Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS).
Idiopathic inflammatorymyopathies are heterogeneous in their pathophysiologic features and prognosis. The emergence ofmyositis-specific autoantibodies suggests that subgroups of patients exist.
In this review, we will describe the immunologic aspects of pregnancy
and tolerance, with an emphasis on the crucial role of vitamin D as a regulatory factor, which contributes to the prevention of immune-mediated Recurrent pregnancy loss.
Since the peripheral cytokines, produced after the injection of the vaccines, are able to reach the central nervous system, we hypothesize that these cytokines can have effects on the microglia (macrophages of the central nervous system), and that these effects can be facilitated by repeated vaccinations to infants during the first year of life.
Smoking is Associated with low levels of soluble PD-L1 in Rheumatoid Arthritis