The use of vaccines including aluminum (Al)–based adjuvants is widespread among small ruminants and other animals. They
are associated with the appearance of transient injection site nodules corresponding to granulomas.
3 hours ago
Aluminum (Al)-containing vaccines are common in sheep management and they have been associated with the Autoimmune/inflammatory Syndrome Induced by Adjuvants
(ASIA syndrome). The aim of this study was to investigate cognitive and behavioral changes in sheep subjected to a protocol of repetitive inoculation with Al-containing products.
3 days ago
Objective: Interstitial lung disease (ILD) is the most severe complication of idiopathic inflammatory myositis
(IIM), resulting in significant increase in morbidity and mortality and for which the best treatment remains controversial. We conducted a meta-analysis to evaluate the efficacy of therapies used for the management of IIM-related ILD
5 days ago
Dampness and Mold Hypersensitivity Syndrome (DMHS) associates
with several other neglected medical conditions such as the Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)  and Multiple Chemical Sensitivity (MCS)
6 days ago
Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation.
10 days ago
Systemic lupus erythematosus (SLE) is a prototypic chronic, multiorgan autoimmune disease characterized by immune complex deposition and vasculopathy, and, therefore, can affect any organ and tissue of the human body.
Despite major recent advances in the therapeutic management of Giant cell arteritis (GCA), the diagnosis accuracy of temporal artery ultrasound remains controversial in this disease. We performed a systematic review to determine the sensitivity, specificity, and summary positive (LR+) and negative (LR-) likelihood ratios of
temporal artery ultrasound for the diagnosis of GCA.
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin
plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system.
Interstitial lung disease (ILD) is the leading cause of death
in patients with systemic sclerosis (SSc). Randomized controlled trials have favored the use of cyclophosphamide (CYC) for treating SSc-ILD3,4,5. Compared with placebo, 1 year of CYC improved lung function in patients with SSc-ILD in Scleroderma Lung Study (SLS) I3
By targeting inhibitory checkpoint molecules, with resultant
reinvigoration of antitumor immunity, immune checkpoint inhibitors (ICIs) have opened a new chapter in cancer treatment .