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Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases Revisited

 

 

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Recent Articles
Systemic Sclerosis (SSc) is a rare autoimmune disease that is characterized by progressive skin fibrosis, an obliteration of the microvasculature and an exaggerated extracellular matrix deposition, which lead to multisystemic dysfunction.
7 days ago
 
This study presents interferon-alpha (IFN-α)-induced persistent fatigue as a model of CFS. IFN-α, which is used in the treatment of chronic Hepatitis C Virus (HCV) infection, induces persistent fatigue in some individuals, which does not abate post-treatment, that is, once there is no longer immune activation.
8 days ago
 
Autoimmune rheumatic diseases including systemic lupus erythematosus, rheumatoid arthritis, Sjogren's Syndrome and progressive systemic sclerosis require both a genetic predisposition and an environmental exposure for disease onset and flares, and two or more of these diseases can develop in the same patient.
9 days ago
 
Close to 30 years ago we [Y.S. et al.] came up with the notion that autoimmune diseases share a common background which they had termed the mosaic of autoimmunity.
20.12.2018
 
Several epidemiological studies have investigated the link between silicone breast implants (SBIs) and autoimmune/rheumatic disorders, reporting inconsistent results. We aimed to evaluate the association between SBIs and the most clinically relevant autoimmune/rheumatic disorders using a large, population-based database.
05.12.2018
 
HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3]. Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and antithrombotic various effects [4–16]. Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency.
05.12.2018
 
The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the available data are scarce. The aim of our study was to characterise the faecal fungal microbiota in patients with IBD.
04.12.2018
 
Our objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses’ Health Study (NHS, 1984–2014) and 93,572 women in the NHSII (1991–2013); incident RA was confirmed by medical records.
04.12.2018
 
The objective of this article was to establish the clinical course of interstitial lung disease (ILD) in scleroderma related to the presence of anti-PM/Scl antibody compared with anti-Scl-70 in a Spanish cohort. Furthermore, no study has thoroughly investigated the outcome of pulmonary function test in the first group of patients.
27.11.2018
 
Giant cell arteritis (GCA) is an autoimmune disorder which primarily affects large vessels, whilst inflammatory bowel diseases (IBD) mainly target the gut. Co-existence of the two maladies has been reported sporadically in the literature; therefore the purpose of this study was to assess the authenticity of such an association in a large, cross-sectional study.
27.11.2018
 
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