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Updates from Autoimmunity 2018

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Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases Revisited

 

 

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Recent Articles
Organ specific immune-related adverse events are uncommon with anti-PD-1 drugs but the risk is increased compared with control treatments. General adverse events related to immune activation are largely similar. Adverse events consistent with musculoskeletal problems are inconsistently reported but adverse events may be common.
2 hours ago
 
Poriasis is a common chronic inflammatory disease that affects 1% to 2% of the general population of all ages. It is thought that in genetically predisposed individu- als, psoriasis is triggered by environmental factors that vary over the course of life, such as trauma, infections, stress, smok- ing, and the consumption of certain drugs and alcohol. Pa- tients with psoriasis show a greater prevalence of obesity and metabolic syndrome, both of which confer a higher cardio- vascular risk. Inflammation could be the link between pso- riasis and obesity. Diet can play an important role in psoria- sis. It includes many proinflammatory (eg, saturated fatty acids, heme, iron) and anti-inflammatory (eg, dietary fibers, some polyphenols) bioactive compounds
3 hours ago
 
Characterized by chronic widespread pain, generalized hyperalgesia, and psychological stress fibromyalgia (FM) is difficult to diagnose and lacks effective treatments. This case -control study compared the concentration differences of AEA, OEA, PEA, SEA, and 2-AG in 104 women with FM and 116 healthy controls (CON). All participants rated their pain, anxiety, depression, and current health status. The relationships between the lipid concentrations and the clinical assessments were investigated using powerful multivariate data analysis and traditional bivariate statistics.
3 hours ago
 
The antibody-mediated encephalitides occur in persons of all ages, with some types affecting predominantly children and young adults. Certain syndromes are recognizable on clinical grounds, and their autoimmune cause can be established with laboratory tests. Despite the severity of symptoms, prompt diagnosis and treatment lead to improvement or full recovery in most cases.
10 days ago
 
Cognitive impairment is a significant clinical problem both in multiple sclerosis (MS) and systemic lupus erythematosus (SLE) patients. In MS cognitive dysfunction has been associated with brain atrophy and total demyelinating lesion volume. In SLE cognitive impairment is much less understood, and its link to structural brain damage remains to be established.
10 days ago
 
Minocycline is a semi-synthetic antimicrobial which, in addition to its role in infectious disease, has garnered roles in the management of acne vulgaris, acne rosacea, and a variety of novel clinical applications (1). In the context of a potentially expanding population on protracted treatment courses, immune-mediated adverse effects, although rare, remain important to recognize.
14 days ago
 
The safety of treatment with biological disease-mod- ifying antirheumatic drugs (bDMARD) has been carefully studied for the past 15 years; however, it is still largely unknown whether this treatment is safe in patients with arthritis with a history of cancer.
14 days ago
 
The main objective of this study was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role.
14 days ago
 
Organ specific immune-related adverse events are uncommon with anti-PD-1 drugs but the risk is increased compared with control treatments. General adverse events related to immune activation are largely similar. Adverse events consistent with musculoskeletal problems are inconsistently reported but adverse events may be common.
29.07.2018
 
Regular physical activity (PA) is increasingly promoted for people with rheumatic and musculoskeletal diseases as well as the general population. This article provides the evaluation of if the public health recommendations for PA are applicable for people with inflammatory arthritis (iA; Rheumatoid Arthritis and Spondyloarthritis) and osteoarthritis (hip/knee OA) in order to develop evidence-based recommendations for advice and guidance on PA in clinical practice.
29.07.2018
 
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