Janus kinase (JAK) inhibitors are a relatively new addition to our tools for treatment of rheumatoid arthritis (RA)1. They are responsible for transduction of more than 38 cytokinases2, with diffuse metabolic/immunologic implications.
Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to patients with systemic sclerosis, Alzheimer’s disease, and ovarian cancer
The use of vaccines including aluminum (Al)–based adjuvants is widespread among small ruminants and other animals. They
are associated with the appearance of transient injection site nodules corresponding to granulomas.
Aluminum (Al)-containing vaccines are common in sheep management and they have been associated with the Autoimmune/inflammatory Syndrome Induced by Adjuvants
(ASIA syndrome). The aim of this study was to investigate cognitive and behavioral changes in sheep subjected to a protocol of repetitive inoculation with Al-containing products.
Objective: Interstitial lung disease (ILD) is the most severe complication of idiopathic inflammatory myositis
(IIM), resulting in significant increase in morbidity and mortality and for which the best treatment remains controversial. We conducted a meta-analysis to evaluate the efficacy of therapies used for the management of IIM-related ILD
Dampness and Mold Hypersensitivity Syndrome (DMHS) associates
with several other neglected medical conditions such as the Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)  and Multiple Chemical Sensitivity (MCS)
Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation.
Systemic lupus erythematosus (SLE) is a prototypic chronic, multiorgan autoimmune disease characterized by immune complex deposition and vasculopathy, and, therefore, can affect any organ and tissue of the human body.
Despite major recent advances in the therapeutic management of Giant cell arteritis (GCA), the diagnosis accuracy of temporal artery ultrasound remains controversial in this disease. We performed a systematic review to determine the sensitivity, specificity, and summary positive (LR+) and negative (LR-) likelihood ratios of
temporal artery ultrasound for the diagnosis of GCA.
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin
plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system.